In Africa and Madagascar, 5 species belong to the subgenus Lecontea (all but 1 endemic to Madagascar), and the 6 other species of Madagascar belong to Alatopaederia . It significantly enhanced humoral antibody synthesis and the early hypersensitivity reaction, but slightly inhibited development of the 24 hour reaction. Root induction was observed in MS media supplemented with 0.25 mg BAP + 0.5 mg indole butyric acid (IBA) within 12 days of culture. Bruised aerial parts of the plant have the fetid odour of indole (methyl-mercaptan). Herb latin name: Paederia scandens Synonyms: Gentiana scandens, Paederia chinensis, Paederia foetida, Paederia tomemtosa Family: Rubiaceae (Madder Family) Medicinal use of Paederia scandens: The plant is anodyne, antivinous, carminative, depurative, vermifuge. The leaves are also used to treat hepatic disorders and rheumatism. De, S., Ravishankar, B. In this study, experiments were designed to develop regeneration protocols for the propagation as well as conservation of a rare medicinal plant, Paederia foetida (L.) MEDICINAL VALUES OF SKUNK VINE (Paederia foetida L.)-AN OVERVIEW Seedling with epigeal germination; cotyledons broadly rounded, veins prominent; first pair of leaves elliptical, apex acuminate. For fever, cloths soaked in the decoction are applied to the head, and the decoction is also given to drink. The word meaning of Gandha Prasarini in Sanskrit is – it spreads bad smell! Antiarthritic activity: Paederia foetida extract was tested for its effect on osteoarthritis-like lesions induced in the knee joints of rabbits by ananase (the proteolytic enzyme from pineapple). Flowers bisexual, usually 5-merous, dirty pink or lilac, or purplish, corolla lobes pinkish to whitish inside, throat dark purple; calyx campanulate, 5-lobed, lobes triangular, up to 1 mm × 0.6 mm, normally glabrous; corolla cylindrical to bell-shaped, 5-17 mm × 2-5 mm, throat and inside of tube densely long-hairy, lobes 5, oblong to triangular, 1-3 mm × 1.5-3 mm, margins wavy, inflexed; stamens 5, inserted in the middle of the tube, included, anthers 2-2.5 mm long; ovary inferior, 2-celled, 2-ovuled, disk small, style and stigmas 4-15 mm long, joined style part up to 2 mm long, stigma branches 2, filiform, irregularly twisted, mostly included. Antispasmodic activity: A 50% ethanolic extract of Paederia foetida exhibited antispasmodic activity on the isolated guinea pig ileum. Singh, S., Ray, B.K., Mathew, S., Buragohain, P., Gogoi, J., Gogoi, S., Sharma, B.K. The leaves are anodyne, antirheumatic, antivinous, astringent, carminative, depurative, diuretic, restorative and vermifuge [147, 218, 310 ]. Fruit a drupe, (sub)globose, 4-6 mm in diameter, walls thin, dry, brittle, crowned by the persistent sepals, shiny pale brown to yellowish- or reddish-brown; pyrenes 2, semi-orbicular or semi-ellipsoidal, plano-convex or compressed, slightly smaller than fruit, without conspicuous wings, black, often conspicuously covered with raphides. Whole plant is used in Indian System of Medicines. are present in this plant [4, 5, 6]. & Deka, P.C., 1999. 147. Publications and Information Directorate, New Delhi, India.236, 250, 264, 331, 407, 552, 786, 788, 803, 810, 841, 926, 1076. The leaves of P. foetida are widely used in Asia and South-East Asia for the treatment of intestinal complaints such as colic, cramps, flatulence, dysentery and also for rheumatism and gout. Linalool is the major component of the oil obtained from the stem, leaf and flower, together with a-terpineol and geranio1.2 The leaf and stem also contain hentriacontane, hentriacontanol and ceryl alcohol, 2,3-dihydrobenzofuran, benzofuran and the sulphur-containing compounds dimethyl sulphide and dimethyl trisulphide. No. 1 (A-H) pp. Especially the disease-modifying component merits attention. • Anti-arthritic activity: It is very useful in the treatment of joint problems like arthritis and joint pain, gout etc. The plant is grown in East Asia. In the Philippines, the bark or the root is considered emetic, and the leaves are used in antirheumatic baths. 2 volumes. It reduced the degradation changes in the articular cartilage induced by ananase and in vitro studies using ananase-treated chick embryonic bones showed that the plant (at a dose of 10 mg/ml of the medium) enhanced the growth of the chick bones cultivated in this medium. P. foetida is harvested from the wild whenever needed. The plant is having a broad spectrum of use as in treatment of hepatic disorders, rheumatoid arthritis, A decoction of the whole plant is used in the treatment of abdominal pain, abscesses, arthritis, overeating etc[147, 218]. (PF) leaf extract in the streptozotocin induced diabetic rats. The most abundant sulphur-containing compound was dimethyl disulphide. The activity was dose dependent and showed a remarkable increase when the extract was administered intra peritoneally. The LDso of a 50% ethanolic extract of leaves was 1200 mg/kg in mice. Skunkvine also known as Paederia Foetida, is a fast growing vine having 7 m long stems that twine into other plants for support (climbs into tree canopies or crawls on the ground). Over the past decade, herbal and ayurvedic drugs have become a subject of world importance, with both medicinal and economical implications. Mekong Printing, Santa Ana, California, United States. There are no known breeding programmes of P. foetida . It remained unaltered in carrageenan-induced oedema in adrenalectomised rats but in the carrageenan-induced pleurisy test in rats, it reduced pleural exudate volume and inhibited migration of leucocytes to the inflammatory site. Fitoterapia 65(4): 357-362. P. foetida has (sub)globose fruits and a very wide distribution in South-East Asia while P. cruddasiana Prain has laterally compressed-ovoid fruits, which are distinctly winged, and which occurs from northern India, Bangladesh, Nepal, Bhutan to south-western China and Thailand. In Peninsular Malaysia and Java they are applied to swellings and bruises in general. Antiarthritic activity: Paederia foetida extract was tested for its effect on osteoarthritis-like lesions induced in the knee joints of rabbits by ananase (the proteolytic enzyme from pineapple). ]. It also inhibited the elevation of serum orosomucoid levels in rats, suggesting the possibility of the presence of disease-modifying antirheumatic activity. Gandha Prasarini (Paederia foetida) is an important Ayurvedic medicinal herb. The hepatoprotective potential of a leaf methanol extract has been assessed against CCl4-induced liver damage in the rat model. The percentage of antioxidant activity for all extract samples using both assays was between 58 and 80%. In addition, scandoside was found to promote the growth of lettuce seedlings. The fruits are used to prevent toothache. Journal of Ethnopharmacology 43(1): 31-38. Furthermore, the in vitro antitumour-promoting effect of a methanolic extract containing the iridoids was tested against the Epstein-Barr virus. In India and Indo-China, the stem, leaves and seeds are applied specifically for rheumatism, alone or in mixtures with other plants. Ayurvedic medicine with Paederia foetida- Prasarini Thailam – used in arthritis, sciatica etc. Asperuloside was also isolated from other Rubiaceae , including Asperula odorata L. and several Coprosma species. The root is also used as an emetic. The main use The main use of the plant is for arthritis and:rheumatic disorders. It has been found in Chinese herbalist shops in Peninsular Malaysia. Paederia foetida and P. scandens are two important and well explored Paederia species (Rubiaceae). Maha Narayan Oil – widely used pain relieving massage oil Marma Gulika– used in disorders of heart, kidney etc. They are commonly used for the treatment of intestinal complaints such as abdominal pain, colic, cramps, flatulence and dysentery; and are also used for treating rheumatism and gout [. The stem yields a strong and silky fibre, but it is not commercially exploited. Inhibitory effect of iridoids on Epstein-Barr virus activation by a short-term in vitro assay for anti-tumor promoters. It is a host for the root-knot nematode Meloidogyne sp. asperuloside, scandoside and paederoside were isolated from the aerial parts of P. foetida . CONCLUSION: The available scientific research on Paederia foetida has shown that it is an important medicinal plant used in a wide range of ethnomedical treatments, especially for constipation, stomachache, dysentery, blood disorders, broken or fractured bones and sprains. In India, the leaves are often boiled in soup to lessen their smell. P. foetida is used on a local scale only. Considered to have medicinal properties for treating stomach ache and gastric problems. Parts of P. foetida are mainly used fresh, but can be dried for later use. Paederoside showed a similar inhibitory activity to that of asperuloside and daecetyl-asperulosidic acid in a plant growth inhibition test and in an antimicroorganism activity test. Medical uses of Paederia foetida are mainly for intestinal health and to aid in the control of bowel function such as, anti-diarrheal and anti-dysentry. It reduced the degradation changes in the articular cartilage induced by ananase and in vitro studies using ananase-treated chick embryonic bones showed that the plant (at a dose of 10 mg/ml of the medium) enhanced … 367-368. It may help to eliminate poisons collected in the system. Inflorescence a terminal or axillary cymose panicle, extremely variable, from widely branched paniculate, over 1 m long to rather reduced, 10 cm long; bracts foliaceous or small and linear, with few to numerous flowers, often in lax scorpioid cymes; peduncle 2-30 mm long. Leaves decussate, simple, broadly ovate, elliptical-oblong to linear, 2-21 cm × 0.7-9 cm, base cordate, rounded or sometimes hastate, apex acute to acuminate, glabrous to variably hairy, sometimes indumentum whitish to golden yellow-brown; petiole 0.5-6(-9) cm long; stipules interpetiolar, rounded or ovate to triangular, 1.5-5 mm × 2-3 mm, usually entire, glabrous or hairy. Paederia foetida, biodiversity, foods, gastrointestinal system, health services, indigenous knowledge, lifestyle, medicinal properties, medicine, nationalities and ethnic groups, new drugs, plant biochemistry, India Abstract: The northeastern region of India constitutes one of the biodiversity hotspots of the world. The leaves of P. foetida are widely used in Asia and South-East Asia for the treatment of intestinal complaints such as colic, cramps, flatulence, dysentery and also for rheumatism and gout. Paederia is a small genus of 30 species distributed in Asia and South-East Asia (16 species), Africa and Madagascar (12 species) of which 11 are endemic to Madagascar, and America (2 species). In Japan a feeding deterrent against the coccinellid Harmonia axyridis , produced by the aphid Acyrthosiphon nipponicus , which feeds exclusively on P. foetida , was identified as a paederoside. Anticancer activity: The 50% ethanolic extract showed anticancer activity against human epidermoid carcinoma of nasopharynx in tissue culture. For intestinal problems, fresh leaves are pounded, water added, and the … The latter compound also contains an unusual S-methylcarbonate function. Home | About Us | Herbs A to Z | Terms & Conditions | Contact Us, Copyright © Krishna Herbal Company 2018. Damage to the tissue releases an enzyme which splits off this sulphur-containing group from paederoside, and is therefore responsible for the unpleasant odour. Anti-inflammatory activity of Paederia foetida. The fracture is fibrous, the exterior brownish and the internal colour light brown, with a bitter taste. Sometimes, shoots produce adventitious roots when they come in contact with the soil, and can thus be propagated as well. The primary objective of the present investigation is to evaluate the antidiabetic, antihyperlidemic and antioxidant activity of the methanolic extract of the Paederia foetida Linn. Opera Botanica Belgica 3: 167 -178. Backhuys Publishers, Leiden. Micropropagation is also successful. Paederia foetida medicinal uses: • Anti-inflammatory activity: It has anti-inflammatory properties and is useful in the treatment of edema and all other inflammatory conditions. In India, P. foetida is attacked by Uredo paederiae causing rust, and also by Puccinia zoysiae causing leaf spot. Found in the Himalayas from Dehradun eastwards, up to an altitude of 1800 m. It is also found in Bihar, Orissa, Bengal and Assam. There is very limited evidence to … Paederia foetida Linn. They are used to increase infertility and treat paralysis. The leaves, in the form of a poultice, are applied to the abdomen to . In the carrageenan pleurisy test in rats, it reduced the pleural exudate volume and inhibited the migration of leucocytes into the inflammatory site. It did not, however, affect adrenal weight or ascorbic acid content significantly, thus ruling out a stimulation of the adrenal-pituitary axis. Paederia foetida is an indigenous plant belongsto family Rubiaceae. Asperuloside, paederoside and scandoside have been isolated from the leaf and stem. The roots are used as an emetic and the juice extracted from the roots is given in cases of inflammation of the spleen and for pains in the chest and liver. The leaf contains a mixture of fatty acids including non-ionic, capric, lauric, myristic, arachidic and palmitic acids. Puff, C. (Editor), 1991. About 70% of these plantlets were successfully transferred to soil. 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